P52
نویسندگان
چکیده
منابع مشابه
Stabilization of RelB requires multidomain interactions with p100/p52.
The NF-kappaB family member RelB has many properties not shared by other family members such as restricted subunit association and lack of regulation by the classical IkappaB proteins. We show that the protein level of RelB is significantly reduced in the absence of p100 and reduced even more when both p100 and p105 are absent. RelB stabilizes itself by directly interacting with p100, p105, and...
متن کاملMELATONIN SUPPRESSES MACROPHAGE CYCLOOXYGENASE-2 AND INDUCIBLE NITRIC OXIDE SYNTHASE EXPRESSION BY INHIBITING p52 ACETYLATION AND BINDING Running head: Melatonin inhibits p52 binding and acetylation
Melatonin has been shown to be produced by non-pineal cells and possess anti-inflammatory actions in animal models. In the present study, we tested the hypothesis that melatonin suppresses the expression of pro-inflammatory genes such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) by a common transcriptional mechanism. Melatonin but not tryptophan or serotonin inhibited ...
متن کاملInhibitor of p52 NF-κB subunit and androgen receptor (AR) interaction reduces growth of human prostate cancer cells by abrogating nuclear translocation of p52 and phosphorylated ARser81
Accumulating evidence shows that androgen receptor (AR) activation and signaling plays a key role in growth and progression in all stages of prostate cancer, even under low androgen levels or in the absence of androgen in the castration-resistant prostate cancer. Sustained activation of AR under androgen-deprived conditions may be due to its interaction with co-activators, such as p52 NF-κB sub...
متن کاملP52. A new pathway of tumour antigen loading of human dendritic cells via intercellular communication
Background Most cancer cells down-regulate gap junctions (GJ) resulting in loss of communication with their surrounding microenvironment. We have previously shown that infection of mouse tumour cell lines with Salmonella induces the up-regulation of connexin 43 (Cx43), a ubiquitous protein that forms GJs. This up-regulation allows the transfer of antigens between tumour cells and dendritic cell...
متن کاملPasteurella multocida P52 aroA mutant conferred protection to rabbits and mice against haemorrhagic septicaemia
Pasteurella multocida serotype B:2 is the etiological agent of haemorrhagic septicaemia (HS) in cattle and buffaloes, a disease that causes significant economic losses to the dairy industry in India. Several killed vaccines are in uses that provide protection to limited period of time. The aim of this study was to generate an attenuated strain of Pasteurella multocida P52 by targeted gene knock...
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ژورنال
عنوان ژورنال: European Journal of Cancer Supplements
سال: 2015
ISSN: 1359-6349
DOI: 10.1016/j.ejcsup.2015.08.114